Maternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …

It has recently emerged that microglia, the tissue-resident macrophages of the central
nervous system, play significant non-innate immune roles to support the development …

The rubber antioxidant 6PPD has gained significant attention due to its highly toxic
transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of …

Compromised placental function or premature loss has been linked to diverse
neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a …

With the rapid generation of spatial transcriptomics (ST) data, integrative analysis of multiple
ST datasets from different conditions, technologies and developmental stages is becoming …

During development of the central nervous system (CNS), neurons polarize and rapidly
extend their axons to assemble neuronal circuits. The growth cone leads the axon to its …

The central nervous system hosts parenchymal macrophages, known as microglia, and non-
parenchymal macrophages, collectively termed border-associated macrophages (BAMs) …

Mechanical forces and tissue mechanics influence the morphology of the developing brain,
but the underlying molecular mechanisms have been elusive. Here, we examine the role of …

Myelination depends on the maintenance of oligodendrocytes that arise from
oligodendrocyte precursor cells (OPCs). We show that OPC-specific proliferation …

Interspecies blastocyst complementation (IBC) provides a unique platform to study
development and holds the potential to overcome worldwide organ shortages. Despite …