Bone cancers are characterised by the development of tumour cells in bone sites,
associated with a dysregulation of their environment. In the last two decades, numerous …

Prostate cancer (PCa) is the second most common malignancy among men worldwide.
Although early-stage disease is curable, advanced stage PCa is mostly incurable and …

We evaluated the contribution of three genetic alterations (p53 knockdown, K-RASV12, and
mutant EGFR) to lung tumorigenesis using human bronchial epithelial cells (HBEC) …

BACKGROUND.: Cancer of the cervix occurs in∼ 500000 women worldwide each year, with
prognosis highly dependent on disease stage at diagnosis. Survival times are poor and …

Prostate cancer is the second highest cause of cancer-related deaths of men in the US.
Signal transducers and activators of transcription (STATs) proteins are a small family of …

There is increasing evidence that prostate cancers in rodent models and in men contain a
cellular subpopulation that displays stem cell properties. These prostate cancer stem cells …

Flavonoids constitute a large class of polyphenolic compounds with cancer preventative
properties. We have examined the ability of the natural flavone diosmetin to inhibit …

Although the blockade of the hedgehog cascade by using cyclopamine has been reported to
inhibit the growth of some cancer cell types, few studies on the mechanism by which this …

The epidermal growth factor receptor (EGFR) and hedgehog cascades provide a critical role
in prostate cancer progression and contribute to the resistance to clinical therapies and …

Expression of AP-1 proteins has been associated with a more aggressive clinical outcome in
prostate cancer. However, their role and regulation by upstream kinase pathways in …