The process of malignant transformation in paediatric acute leukaemias is complex,
requiring at least two deleterious events resulting in DNA damage. This damage ranges …

Newborns and children with Down syndrome (DS) often present with congenital transient
leukemia and have an increased risk of acute myeloid leukemia and acute lymphoblastic …

Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at
relatively low frequency in acute myeloid leukemia (AML) but can be missed with routine …

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on
the principles of leukaemia diagnosis and classification has been fully updated, and …

Background Chimeric antigen receptor (CAR)-T cells have emerged as a breakthrough
treatment for relapse/refractory hematological tumors, showing impressive complete …

The spectrum of chromosomal abnormality associated with leukemogenesis of acute
myeloid leukemia (AML) is broad and heterogeneous when compared to chronic myeloid …

Participation of clinical genetic laboratories in External Quality Assessment schemes (EQAs)
is a powerful method to ascertain if any improvement or additional training is required in the …

It is well known that varying degrees of mosaicism for Trisomy 21, primarily a combination of
normal and Trisomy 21 cells within individual tissues, may exist in the human population …

Interstitial deletion of chromosome 5q is the most common chromosomal abnormality in
myelodysplastic syndromes. The catalogue of genes involved in the molecular pathogenesis …

The chromosome number of human tumors varies widely, from near‐haploidy to more than
decaploidy. Overt hyperhaploid (24–34 chromosomes) tumors constitute a small minority …