Tumour necrosis factor (TNF) is a primary mediator of inflammatory processes by facilitating
cell death, immune cell activation and triggering of inflammation. In the cancer context …

Deciphering the cell-state transitions underlying immune adaptation across time is
fundamental for advancing biology. Empirical in vivo genomic technologies that capture …

Cytokine-based therapeutics have been shown to mediate objective responses in certain
tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents …

Antibody-cytokine fusion breathes new life into glioblastoma therapy | Science Translational
Medicine news careers commentary Journals Science Science brought to you byGoogle Indexer …

PARP inhibitors (PARPi) hold substantial promise in treating glioblastoma (GBM). However,
the adverse effects have restricted their broad application. Through unbiased transcriptomic …

Cytokines [1–3] are potent immunoregulatory proteins that have proven to be of relevance
as therapeutic modalities. In this regard, cytokines have been approved for the treatment of a …

Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role
in various cellular processes, including cell proliferation, survival, and metabolism. The …

Reproducible and efficient expansion of different immune effector cells is required for pre-
clinical studies investigating adoptive cell therapies against cancer. Here, we provide a …

Combination of tumour-targeted TNF and chemotherapy shows promising results in glioblastoma
| Nature Reviews Immunology Skip to main content Thank you for visiting nature.com. You are …

Hintergrund: Gliome sind die häufigsten bösartigen primären Hirntumoren bei
Erwachsenen. Trotz multimodaler Therapiekonzepte aus Chirurgie, Bestrahlung und …