Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and
targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 …

Congenital defects of neural tube closure (neural tube defects; NTDs) are among the
commonest and most severe disorders of the fetus and newborn. Disturbance of any of the …

Neural tube defects (NTDs) are common, severe congenital malformations whose causation
involves multiple genes and environmental factors. Although more than 200 genes are …

The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …

Rationale: Phagocytosis of silicon dioxide (SiO 2) into lung cells causes an inflammatory
cascade that results in fibroblast proliferation and migration, followed by fibrosis. Circular …

Excessive proliferation and migration of fibroblasts contribute to pulmonary fibrosis in
silicosis, and both epithelial cells and endothelial cells participate in the accumulation of …

Impaired ribosome function is the underlying etiology in a group of bone marrow failure
syndromes called ribosomopathies. However, how ribosomes are regulated remains poorly …

Epidermal growth factor (EGF) signalling regulates growth and differentiation. Here, we
examine the function of EGF signalling in Caenorhabditis elegans lifespan. We find that EGF …