Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines

Q Fernandes, VP Inchakalody, M Merhi… - Annals of …, 2022 - Taylor & Francis
The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for
change in the form of newer and more adaptive diagnostic methods for the detection of …

Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

NI Mazur, J Terstappen, R Baral, A Bardají… - The Lancet Infectious …, 2023 - thelancet.com
Respiratory syncytial virus is the second most common cause of infant mortality and a major
cause of morbidity and mortality in older adults (aged> 60 years). Efforts to develop a …

[HTML][HTML] Efficacy and safety of an Ad26. RSV. preF–RSV preF protein vaccine in older adults

AR Falsey, K Williams, E Gymnopoulou… - … England Journal of …, 2023 - Mass Medical Soc
Background Respiratory syncytial virus (RSV) can cause serious lower respiratory tract
disease in older adults, but no licensed RSV vaccine currently exists. An adenovirus …

[HTML][HTML] Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind …

MN Ramasamy, AM Minassian, KJ Ewer, AL Flaxman… - The Lancet, 2020 - thelancet.com
Background Older adults (aged≥ 70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …

[PDF][PDF] Background document on the Janssen Ad26. COV2. S (COVID-19) vaccine: background document to the WHO Interim recommendations for use of Ad26. COV2 …

World Health Organization - 2021 - apps.who.int
Background This background document was prepared by the Strategic Advisory Group of
Experts (SAGE) on Immunization Working Group on COVID-19 Vaccines to inform the …

[HTML][HTML] Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

JR Barrett, S Belij-Rammerstorfer, C Dold, KJ Ewer… - Nature medicine, 2021 - nature.com
More than 190 vaccines are currently in development to prevent infection by the novel
severe acute respiratory syndrome coronavirus 2. Animal studies suggest that while …

Safety and efficacy of single-dose Ad26. COV2. S vaccine against Covid-19

J Sadoff, G Gray, A Vandebosch… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background The Ad26. COV2. S vaccine is a recombinant, replication-incompetent
human adenovirus type 26 vector encoding full-length severe acute respiratory syndrome …

Interim results of a phase 1–2a trial of Ad26. COV2. S Covid-19 vaccine

J Sadoff, M Le Gars, G Shukarev… - … England Journal of …, 2021 - Mass Medical Soc
Background Efficacious vaccines are urgently needed to contain the ongoing coronavirus
disease 2019 (Covid-19) pandemic of infection with severe acute respiratory syndrome …

[HTML][HTML] Learning from the past: development of safe and effective COVID-19 vaccines

S Su, L Du, S Jiang - Nature Reviews Microbiology, 2021 - nature.com
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
elicited an equally rapid response aiming to develop a COVID-19 vaccine. These efforts are …

Safety and immunogenicity of a respiratory syncytial virus prefusion F (RSVPreF3) candidate vaccine in older adults: phase 1/2 randomized clinical trial

I Leroux-Roels, MG Davis, K Steenackers… - The Journal of …, 2023 - academic.oup.com
Background The aim of this study was to investigate safety and immunogenicity of vaccine
formulations against respiratory syncytial virus (RSV) containing the stabilized prefusion …