This review describes the unique opportunities and challenges for noninvasive optical
mapping of human brain function. Diffuse optical methods offer safe, portable, and radiation …

Near-infrared spectroscopy (NIRS) is an optical technique that can measure brain tissue
oxygenation and haemodynamics in real-time and at the patient bedside allowing medical …

We present the design and characterization of a large-area, fast-gated, all-digital single-
photon detector with programmable active area, internal gate generator, and time-todigital …

Light scattering by tissue severely limits how deep beneath the surface one can image, and
the spatial resolution one can obtain from these images. Diffuse optical tomography (DOT) is …

We present a systematic characterization of the optical properties (µ_a and µ_s') of nine
representative ex vivo porcine tissues over a broadband spectrum (650-1100 nm). We …

Time-domain diffuse optics is a powerful non-invasive, non-ionizing and label-free
technique based on the use of picosecond pulsed laser light to probe highly scattering …

Light has broad applications in medicine as a tool for diagnosis and therapy. Recent
advances in optical technology and bioelectronics have opened opportunities for wearable …

This work reviews physical concepts, technologies and applications of time-domain diffuse
optics based on time-gated single-photon detection. This particular photon detection …

This review presents recent developments and a wide overview of broadband time domain
diffuse optical spectroscopy (TD-DOS). Various topics including physics of photon migration …

We present the application to time-domain diffuse optics of a high-speed 8× 256 array of
single-photon avalanche diodes with integrated 256 parallel time-to-digital converters …