Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Exosome-shuttled miR-672-5p from anti-inflammatory microglia repair traumatic spinal cord injury by inhibiting AIM2/ASC/Caspase-1 signaling pathway mediated …

Z Zhou, C Li, T Bao, X Zhao, W Xiong, C Luo… - Journal of …, 2022 - liebertpub.com
Traumatic spinal cord injury (TSCI) is a devastating traumatic disease of the central nervous
system, which leads to refractory loss of motor and sensory function. So far, there is no …

[HTML][HTML] Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury

F Gong, T Ge, J Liu, J Xiao, X Wu, H Wang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is the main cause of severe damage to the central nervous system
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …

[HTML][HTML] Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosis

S Yao, M Pang, Y Wang, X Wang, Y Lin, Y Lv, Z Xie… - Redox Biology, 2023 - Elsevier
Ferroptosis is a newly discovered form of iron-dependent oxidative cell death and drives the
loss of neurons in spinal cord injury (SCI). Mitochondrial damage is a critical contributor to …

A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair

X Liu, L Zhang, Z Xu, X Xiong, Y Yu, H Wu, H Qiao… - Acta Biomaterialia, 2022 - Elsevier
MicroRNA (miRNA)-based therapies have shown great potential in the repair of spinal cord
injury (SCI). MicroRNA 21 (miR21) has been proven to have an essential protective effect on …

The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

H Wang, X Zhou, C Li, S Yan, C Feng, J He… - Journal of hematology & …, 2022 - Springer
Pediatric cancers are the driving cause of death for children and adolescents. Due to safety
requirements and considerations, treatment strategies and drugs for pediatric cancers have …

Sodium selenite promotes neurological function recovery after spinal cord injury by inhibiting ferroptosis

YX Chen, T Zuliyaer, B Liu, S Guo… - Neural Regeneration …, 2022 - journals.lww.com
Ferroptosis is a recently discovered form of iron-dependent cell death, which occurs during
the pathological process of various central nervous system diseases or injuries, including …