SWI/SNF nucleosome remodellers and cancer

BG Wilson, CWM Roberts - Nature Reviews Cancer, 2011 - nature.com
SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel
nucleosomes and to modulate transcription. Growing evidence indicates that these …

Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

Y Tang, J Wang, Y Lian, C Fan, P Zhang, Y Wu, X Li… - Molecular cancer, 2017 - Springer
Chromatin remodeling controls gene expression and signaling pathway activation, and
aberrant chromatin structure and gene dysregulation are primary characteristics of human …

DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

BJ Belin, T Lee, RD Mullins - Elife, 2015 - elifesciences.org
Actin filaments assemble inside the nucleus in response to multiple cellular perturbations,
including heat shock, protein misfolding, integrin engagement, and serum stimulation. We …

Active maintenance of nuclear actin by importin 9 supports transcription

J Dopie, KP Skarp, E Kaisa Rajakylä… - Proceedings of the …, 2012 - National Acad Sciences
Besides its essential and well established role as a component of the cytoskeleton, actin is
also present in the cell nucleus, where it has been linked to many processes that control …

Visualization of actin filaments and monomers in somatic cell nuclei

BJ Belin, BA Cimini, EH Blackburn… - Molecular biology of the …, 2013 - Am Soc Cell Biol
In addition to its long-studied presence in the cytoplasm, actin is also found in the nuclei of
eukaryotic cells. The function and form (monomer, filament, or noncanonical oligomer) of …

Actin, actin-binding proteins, and actin-related proteins in the nucleus

I Kristó, I Bajusz, C Bajusz, P Borkúti… - Histochemistry and cell …, 2016 - Springer
Extensive research in the past decade has significantly broadened our view about the role
actin plays in the life of the cell and added novel aspects to actin research. One of these new …

Nuclear functions of actin

N Visa, P Percipalle - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
Actin participates in several essential processes in the cell nucleus. Even though the
presence of actin in the nucleus was proposed more than 30 years ago, nuclear processes …

Molecular link between DNA damage response and microtubule dynamics

JM Kim - International journal of molecular sciences, 2022 - mdpi.com
Microtubules are major components of the cytoskeleton that play important roles in cellular
processes such as intracellular transport and cell division. In recent years, it has become …

Targeting chromatin-remodeling factors in cancer cells: promising molecules in cancer therapy

FL Zhang, DQ Li - International Journal of Molecular Sciences, 2022 - mdpi.com
ATP-dependent chromatin-remodeling complexes can reorganize and remodel chromatin
and thereby act as important regulator in various cellular processes. Based on considerable …

NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components

PYT Lu, N Lévesque, MS Kobor - Biochemistry and Cell …, 2009 - cdnsciencepub.com
Chromatin structure is important for the compaction of eukaryotic genomes, thus chromatin
modifications play a fundamental role in regulating many cellular processes. The …