B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …

Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive
clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial …

Although it has long been known that the immune cell composition has a strong prognostic
and predictive value in colorectal cancer (CRC), scoring systems such as the immunoscore …

Only a minority of patients derive long-term clinical benefit from anti-programmed cell death
protein 1 (anti-PD-1) or anti-programmed death-ligand 1 (anti-PD-L1) monoclonal …

The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …

Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Checkpoint proteins are an integral part of the immune system and are used by the tumor
cells to evade immune response, which helps them grow uncontrollably. By blocking these …

Tumor metastasis is an important reason for the difficulty of tumor treatment. Besides the
tumor cells themselves, the tumor microenvironment plays an important role in the process …