There has been increasing attention in the United States to problems of abuse of gamma-
hydroxybutyrate (GHB), with some evidence for problems in other parts of the world as well …

Gammahydroxybutyrate is a naturally occurring metabolite of many mammalian tissues.
Although its administration produces a wide range of pharmacological effects, its normal …

Background: The similarities between the pharmacological effects of the γ‐aminobutyric acid
receptor agonist, baclofen, and the alcohol‐substituting agent, γ‐hydroxybutyric acid, led us …

GHB is used therapeutically and recreationally, although the precise mechanism of action
responsible for its different behavioral effects is not entirely clear. The purpose of this review …

“Club drugs” have become alarmingly popular. The use of 3, 4‐
methylenedioxymethamphetamine (MDMA, Ecstasy) and γ‐hydroxybutyrate (GHB), in …

Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are
resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that …

Abstract γ-Hydroxybutyric acid (GHB) is a short-chain fatty acid that occurs naturally in
mammalian brain where it is derived metabolically from γ-aminobutyric acid (GABA), the …

The present invention provides a solid immediate release dosage form adapted for oral
administration of GHB. The solid immediate release dosage form includes an immediate …

Over the past few years gamma-hydroxybutyrate (GHB) has generated widespread media
interest as a possible 'date rape drug'. Our goal was to examine the extent to which GHB is …

Although preclinical studies suggest that GHB has low likelihood for abuse, case reports
indicate that GHB is abused. This study evaluated the relative abuse liability of GHB in 14 …