Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

The unicellular protozoan parasites of the genus Plasmodium impose on human health
worldwide the enormous burden of malaria. The possibility to genetically modify several …

The prevention of parasite transmission from the human host to the mosquito has been
recognized as a vital tool for malaria eradication campaigns. However, transmission …

Malaria is spread by the transmission of sexual stage parasites, called gametocytes.
However, with Plasmodium falciparum, gametocytes can only be detected in peripheral …

Transgenic luciferase-expressing Plasmodium falciparum parasites have been widely used
for the evaluation of anti-malarial compounds. Here, to screen for anti-malarial drugs …

Conversion from asexual proliferation to sexual differentiation initiates the production of the
gametocyte, which is the malaria parasite stage required for human-to-mosquito …

The tightly controlled induction of Plasmodium falciparum gametocytes in large-scale culture
is a fundamental requirement for malaria drug discovery applications including, but not …

The discovery of new antimalarial drugs able to target both the asexual and gametocyte
stages of Plasmodium falciparum is critical to the success of the malaria eradication …

New reliable and cost-effective antimalarial drug screening assays are urgently needed to
identify drugs acting on different stages of the parasite Plasmodium falciparum, and …

The gametocytes of the malaria parasites are obligate for perpetuating the parasite's life
cycle through mosquitoes, but the sex-specific biology of gametocytes is poorly understood …