[HTML][HTML] Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

[HTML][HTML] Oxidative stress in cytokine-induced dysfunction of the pancreatic beta cell: Known knowns and known unknowns

A Kowluru - Metabolites, 2020 - mdpi.com
Compelling evidence from earlier studies suggests that the pancreatic beta cell is inherently
weak in its antioxidant defense mechanisms to face the burden of protecting itself against …

Carbohydrate intake prior to oral glucose tolerance testing

KR Klein, CP Walker, AL McFerren… - Journal of the …, 2021 - academic.oup.com
With the emergence of glycated hemoglobin as a diagnostic test for diabetes, oral glucose
tolerance tests (OGTTs) have become rare in endocrinology practice. As they have moved …

[HTML][HTML] Electrogenic sodium bicarbonate cotransporter NBCe1 regulates pancreatic β cell function in type 2 diabetes

MR Brown, H Holmes, K Rakshit… - The Journal of …, 2021 - Am Soc Clin Investig
Pancreatic β cell failure in type 2 diabetes mellitus (T2DM) is attributed to perturbations of
the β cell's transcriptional landscape resulting in impaired glucose-stimulated insulin …

[HTML][HTML] It's what and when you eat: an overview of transcriptional and epigenetic responses to dietary perturbations in pancreatic islets

MR Brown, AV Matveyenko - Frontiers in Endocrinology, 2022 - frontiersin.org
Our ever-changing modern environment is a significant contributor to the increased
prevalence of many chronic diseases, and particularly, type 2 diabetes mellitus (T2DM) …

Association between Mediterranean diet and periodontitis among US adults: The mediating roles of obesity indicators

Y Wu, B He, Q Chen, R Yu, Y Wu… - Journal of …, 2024 - Wiley Online Library
Objective This study aimed to assess the association between the Mediterranean diet
(MedDiet) and periodontitis in US adults and to further explore the mediating roles of obesity …

[HTML][HTML] Nutraceutic Potential of Bioactive Compounds of Eugenia dysenterica DC in Metabolic Alterations

LF Santana, S Sasso, DFS Aquino, K de Cássia Freitas… - Molecules, 2022 - mdpi.com
The fruit and leaves of Eugenia dysenterica DC., locally known as cagaita, are rich in
antioxidant glycosylated quercetin derivatives and phenolic compounds that have beneficial …

Genetics and diet shape the relationship between islet function and whole-body metabolism

B Yau, S Madsen, ME Healy… - American Journal …, 2024 - journals.physiology.org
Despite the fact that genes and the environment are known to play a central role in islet
function, our knowledge of how these parameters interact to modulate insulin secretory …

[HTML][HTML] Islet health, hormone secretion, and insulin responsivity with low-carbohydrate feeding in diabetes

CAA Locatelli, EE Mulvihill - Metabolites, 2020 - mdpi.com
Exploring new avenues to control daily fluctuations in glycemia has been a central theme for
diabetes research since the Diabetes Control and Complications Trial (DCCT) …

[HTML][HTML] Blockade of high-fat diet proteomic phenotypes using exercise as prevention or treatment

SF Martinez-Huenchullan, I Shipsey… - Molecular & Cellular …, 2021 - ASBMB
The increasing consumption of high-fat foods combined with a lack of exercise is a major
contributor to the burden of obesity in humans. Aerobic exercise such as running is known to …