Polyphenols are natural organic compounds produced by plants, acting as antioxidants by
reacting with ROS. These compounds are widely consumed in daily diet and many studies …

ABSTRACT Biopharmaceutics Classification System and Biopharmaceutics Drug
Distribution Classification System are complimentary, not competing, classification systems …

COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease
is a virally encoded protein that is essential across a broad spectrum of coronaviruses with …

Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease
is a virally encoded protein that is essential to the viral life cycle across a broad spectrum of …

Passive permeability is a key property in drug disposition and delivery. It is critical for
gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance …

Despite much progress in regulations to improve paediatric drug development, there
remains a significant need to develop better medications for children. For the design of oral …

A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and
physicochemical-property-based strategies to address metabolic stability and …

Organic anion transporters (OATs) are important in the renal secretion, and thus, the
clearance, of many drugs; and their functional change can result in pharmacokinetic …

For ethical and cost-related reasons, use of animals for the assessment of mode of action,
metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in …