Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

Most living beings, including humans, must adapt to rhythmically occurring daily changes in
their environment that are generated by the E arth's rotation. In the course of evolution, these …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Abstract Type 1 diabetes (T1D) is considered a pancreatic beta cell-specific disease that
results in absolute insulin deficiency. Nevertheless, clinical studies from 1940 onwards …

Mesenchymal stem cells (MSC) are uniquely capable of crossing germinative layers borders
(ie are able to differentiate towards ectoderm-, mesoderm-and endoderm-derived cytotypes) …

The relentless nature and increasing prevalence of human pancreatic diseases, in
particular, diabetes mellitus and adenocarcinoma, has motivated further understanding of …

Glutamate represents a key excitatory neurotransmitter in the central nervous system, and
also modulates the function and viability of endocrine cells in pancreatic islets. In insulin …

The β-cells of the islets of Langerhans are embedded in a dense capillary network. The
blood vessels supply the islet cells with nutrients and oxygen, and in turn take up the …

Aims/hypothesis Following on from the emerging importance of the pancreas circadian clock
on islet function and the development of type 2 diabetes in rodent models, we aimed to …

Expansion of functional islet β-cell mass is a physiological process to compensate for
increased insulin demand. Deficiency or pharmacological inhibition of the plasma …