Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular
membranes or indirectly through their tethered components, provoking cellular …

Abstract Background Systemic sclerosis (SSc), with unclear pathophysiology, is a
paradigmatic rheumatic disease of immunity dysfunction-driven multi-organ inflammation …

Background Cervical cancer, which is a significant public health concern in women,
currently lacks effective therapeutic drugs. Matrine, a constituent of the traditional Chinese …

Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated
in various (patho) physiological contexts. During ferroptosis, lipid peroxidation leads to a …

Skin wound healing is a multifaceted and intricate process involving inflammation, tissue
proliferation, and scar formation, all of which are accompanied by the continuous application …

Ferroptosis is a kind of oxidative stress-dependent cell death characterized by iron
accumulation and lipid peroxidation. It can work in conjunction with radiation to increase …

Endothelial cells (ECs) line the inner surface of blood vessels and play a substantial role in
vascular biology. Endothelial dysfunction (ED) is strongly correlated with the initiation and …

The increased permeability of the lung microvascular endothelium is one critical initiation of
acute lung injury (ALI). The disruption of vascular-endothelium integrity results in leakiness …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating
respiratory disorder with high rates of mortality and morbidity, but the detailed underlying …