Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

Polycystic ovary syndrome (PCOS) is a common infertility disorder affecting a significant
proportion of the global population. It is the main cause of anovulatory infertility in women …

The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …

While modernization has dramatically increased lifespan, it has also witnessed the
increasing prevalence of diseases such as obesity, hypertension, and type 2 diabetes. Such …

In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas
(CRISPR-associated) genome editing systems have become one of the most robust …

Abstract Motivation: The recently released Infinium HumanMethylation450 array (the
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …

Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …