Novel and emerging treatments for major depression

S Marwaha, E Palmer, T Suppes, E Cons, AH Young… - The Lancet, 2023 - thelancet.com
Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

Digital interventions for the treatment of depression: A meta-analytic review.

I Moshe, Y Terhorst, P Philippi, M Domhardt… - Psychological …, 2021 - psycnet.apa.org
The high global prevalence of depression, together with the recent acceleration of remote
care owing to the COVID-19 pandemic, has prompted increased interest in the efficacy of …

Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis

A Bahji, GH Vazquez, CA Zarate Jr - Journal of affective disorders, 2021 - Elsevier
Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …

Global trends in the prevalence and incidence of depression: a systematic review and meta-analysis

D Moreno-Agostino, YT Wu, C Daskalopoulou… - Journal of affective …, 2021 - Elsevier
Background There is mixed evidence regarding the change in the prevalence of depression
in the general population over time. This study aimed to synthesise the evidence on studies …

Physical distancing and mental health during the COVID-19 pandemic: Factors associated with psychological symptoms and adherence to pandemic mitigation …

OV Ebrahimi, A Hoffart… - Clinical Psychological …, 2021 - journals.sagepub.com
In this epidemiological investigation, we assessed the prevalence of depression and anxiety
symptoms during the COVID-19 pandemic. A total of 10,061 adults participated in the study …

Mental health problems among female sex workers in low-and middle-income countries: A systematic review and meta-analysis

TS Beattie, B Smilenova, S Krishnaratne… - PLoS …, 2020 - journals.plos.org
Background The psychological health of female sex workers (FSWs) has emerged as a
major public health concern in many low-and middle-income countries (LMICs). Key risk …

[HTML][HTML] Anxiety and depression in adult cancer patients: ESMO Clinical Practice Guideline

L Grassi, R Caruso, MB Riba, M Lloyd-Williams… - ESMO open, 2023 - Elsevier
Anxiety and depression are the most common psychological symptoms in patients with
cancer, irrespective of disease stage, primary cancer site and phase of treatment. Symptoms …

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Mental health and wellbeing in young people in the UK during lockdown (COVID-19)

M Owens, E Townsend, E Hall, T Bhatia… - International Journal of …, 2022 - mdpi.com
This study aimed to assess the levels of mental wellbeing and potential for clinical need in a
sample of UK university students aged 18–25 during the COVID-19 pandemic. We also …

Oral administration of Lactococcus lactis WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress

K Gao, A Farzi, X Ke, Y Yu, C Chen, S Chen, T Yu… - Food & Function, 2022 - pubs.rsc.org
Depression is a mood disorder with a high prevalence rate globally, which is associated with
abnormalities in 5-hydroxytryptamine (5-HT) metabolism. Emerging evidence suggests that …