Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

Even though the importance of epigenetics was first recognized in light of its role in tissue
development, an increasing amount of evidence has shown that it also plays an important …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …

Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Background Genome-wide DNA methylation (DNAm) profiling has allowed for the
development of molecular predictors for a multitude of traits and diseases. Such predictors …

Clinical research and practice in the 21st century is poised to be transformed by analysis of
computable electronic medical records and population-level genome-scale patient profiles …

Background: Cardiovascular health (CVH) from young adulthood is strongly associated with
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …