The prevalence of obesity and diabetes is increasing worldwide. Obesity and diabetes are
associated with oxidative stress, inflammation, endothelial dysfunction, insulin resistance …

The increasing prevalence of type 2 diabetes has become a major global problem. Insulin
resistance has a central role in pathophysiology of type 2 diabetes. Skeletal muscle is …

Among multiple mechanisms, low-grade inflammation is critical for the development of
insulin resistance as a feature of type 2 diabetes. The nucleotide-binding oligomerization …

Sarcopenia, the age-related loss of muscle strength and mass or quality, is a common
condition with major adverse consequences. Although the pathophysiology is incompletely …

Obesity-induced fat ectopic deposition results in mitochondrial dysfunction and oxidative
stress in skeletal muscle, which could impair the quality and function of the skeletal muscle …

As a major site of glucose uptake following a meal, skeletal muscle has an important role in
whole-body glucose metabolism. Evidence in humans and animal models of insulin …

Objective: Vascular endothelial cells (ECs) play a critical role in maintaining vascular
homeostasis. Aberrant EC metabolism leads to vascular dysfunction and metabolic …

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin
sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved …

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …

Background: The excess body fat characteristic of obesity is related to various metabolic
alterations, which includes insulin resistance (IR). Among the non-pharmacological …