The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: a randomized trial

SD Søndergård, I Cintin, AB Kuhlman… - Applied Physiology …, 2021 - cdnsciencepub.com
The effect of oral glutathione (GSH) supplementation was studied in obese subjects with and
without type 2 diabetes (T2DM) on measures of glucose homeostasis and markers of …

Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists

SC Broome, AJ Braakhuis, CJ Mitchell… - Journal of the International …, 2021 - Springer
Background Exercise increases skeletal muscle reactive oxygen species (ROS) production,
which may contribute to the onset of muscular fatigue and impair athletic performance …

Biomarkers of obesity-mediated insulin resistance: focus on microRNAs

Y Cai, P Liu, Y Xu, Y Xia, X Peng, H Zhao… - Diabetology & Metabolic …, 2023 - Springer
Obesity and metabolic syndromes are becoming increasingly prevalent worldwide. Insulin
resistance (IR) is a common complication of obesity. However, IR occurrence varies across …

Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt …

J Yang, S Hamid, J Cai, Q Liu, S Xu, Z Zhang - Cellular Signalling, 2017 - Elsevier
Thioredoxin (Txn) system is the most crucial antioxidant defense mechanism in cell
consisting of Txn, thioredoxin reductase (TR) and Nicotinamide Adenine Dinucleotide …

Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men

L Meng, R Yang, D Wang, W Wu, J Shi, J Shen, Y Dang… - BMC geriatrics, 2022 - Springer
Background Metabolic profiling may provide insights into the pathogenesis and identification
of sarcopenia; however, data on the metabolic basis of sarcopenia and muscle-related …

Antimycin A-induced mitochondrial dysfunction is consistent with impaired insulin signaling in cultured skeletal muscle cells

SE Mazibuko-Mbeje, SXH Mthembu, PV Dludla… - Toxicology in Vitro, 2021 - Elsevier
Insulin resistance and mitochondrial dysfunction are characteristic features of type 2
diabetes mellitus. However, a causal relationship between insulin resistance and …

[HTML][HTML] Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice

BA Kugler, J Lourie, N Berger, N Lin, P Nguyen… - Molecular …, 2023 - Elsevier
Abstract Objective Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial
fission. We and others have reported a strong correlation between enhanced Drp1 activity …

Low-Carbohydrate Diet Modulates Glucose–Lipid Utilization in Skeletal Muscle of Diabetic Mice

Y Li, Z Yang, Y Wang, M Fan, C Nie, L Xue, L Wang… - Nutrients, 2023 - mdpi.com
Type 2 diabetes is associated with many complications, including skeletal muscle atrophy.
Ketogenic diets and low-carbohydrate diets (LCD) have recently been introduced as dietary …

[HTML][HTML] Virgin coconut oil reverses behavioral phenotypes of letrozole-model of PCOS in Wistar rats via modulation of NRF2 upregulation

OO Akintoye, AJ Ajibare, IO Omotuyi - Journal of Taibah University Medical …, 2023 - Elsevier
Polycystic ovarian syndrome (PCOS) is a heterogeneous clinical condition characterized by
anovulation, metabolic imbalances, and endocrine and mental health abnormalities 1 …

Leucine supplementation differently modulates branched-chain amino acid catabolism, mitochondrial function and metabolic profiles at the different stage of insulin …

R Liu, H Li, W Fan, Q Jin, T Chao, Y Wu, J Huang… - Nutrients, 2017 - mdpi.com
The available findings concerning the association between branched-chain amino acids
(BCAAs)—particularly leucine—and insulin resistance are conflicting. BCAAs have been …