5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin receptors are prevalent throughout the nervous system and the periphery, and
remain one of the most lucrative and promising drug discovery targets for disorders ranging …

The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain
functions and is critically involved in many neuropsychiatric disorders. Here, we present a …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Several neurochemical in vitro and in vivo imaging studies have been aimed at
characterizing the localization of serotonin receptors and transporters in the human brain. In …

The external globus pallidus (GP e) of the basal ganglia is in a unique and powerful position
to influence processing of motor information by virtue of its widespread projections to all …

Abstract Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety,
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …