Lipoprotein (a): Knowns, unknowns and uncertainties

M Ruscica, CR Sirtori, A Corsini, GF Watts… - Pharmacological …, 2021 - Elsevier
Over the last 10 years, there have been advances on several aspects of lipoprotein (a)
which are reviewed in the present article. Since the standard immunoassays for measuring …

[HTML][HTML] A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]

S Mack, S Coassin, R Rueedi, NA Yousri… - Journal of lipid …, 2017 - ASBMB
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …

Lipoprotein (a) and cardiovascular risk prediction among women

NR Cook, S Mora, PM Ridker - Journal of the American College of …, 2018 - jacc.org
Abstract Background: Although lipoprotein (a)[Lp (a)] is associated with incident
cardiovascular disease (CVD), its contribution to prediction remains controversial …

[HTML][HTML] Lipoprotein (a): evidence for role as a causal risk factor in cardiovascular disease and emerging therapies

HS Bhatia, MJ Wilkinson - Journal of clinical medicine, 2022 - mdpi.com
Lipoprotein (a)(Lp (a)) is an established risk factor for multiple cardiovascular diseases.
Several lines of evidence including mechanistic, epidemiologic, and genetic studies support …

[HTML][HTML] Deep coverage whole genome sequences and plasma lipoprotein (a) in individuals of European and African ancestries

SM Zekavat, S Ruotsalainen, RE Handsaker… - Nature …, 2018 - nature.com
Abstract Lipoprotein (a), Lp (a), is a modified low-density lipoprotein particle that contains
apolipoprotein (a), encoded by LPA, and is a highly heritable, causal risk factor for …

[HTML][HTML] Consensus document on Lipoprotein (a) from the Italian Society for the Study of Atherosclerosis (SISA)

G Chiesa, MG Zenti, A Baragetti, CM Barbagallo… - Nutrition, Metabolism …, 2023 - Elsevier
Aims In view of the consolidating evidence on the causal role of Lp (a) in cardiovascular
disease, the Italian Society for the Study of Atherosclerosis (SISA) has assembled a …

Lipids, blood pressure and kidney update 2014

M Banach, WS Aronow, C Serban, A Sahabkar… - Pharmacological …, 2015 - Elsevier
This paper is an effort to review all the most important studies and guidelines in the topics of
lipid, blood pressure and kidney published in 2014. Irrespective of advances, the options for …

Lipoprotein (a) and atherosclerotic cardiovascular disease: current understanding and future perspectives

MF Wu, KZ Xu, YG Guo, J Yu, Y Wu, LM Lin - Cardiovascular Drugs and …, 2019 - Springer
Purpose To review current knowledge of elevated lipoprotein (a)[Lp (a)] levels in relation to
atherosclerotic cardiovascular disease (ASCVD) and discuss their potential use as …

[HTML][HTML] CNest: A novel copy number association discovery method uncovers 862 new associations from 200,629 whole-exome sequence datasets in the UK Biobank

T Fitzgerald, E Birney - Cell Genomics, 2022 - cell.com
Copy number variation (CNV) is known to influence human traits, having a rich history of
research into common and rare genetic disease, and although CNV is accepted as an …

Genetic factors explain a major fraction of the 50% lower lipoprotein (a) concentrations in Finns

G Erhart, C Lamina, T Lehtimäki… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Lp (a)(lipoprotein (a)) concentrations are widely genetically determined by the
LPA isoforms and show 5-fold interpopulation differences. Two-to 3-fold differences have …