Sepsis is the host immune imbalance following infection and leads to organ dysfunction,
with highly complicated pathophysiology. To date, sepsis still lacks effective therapies with …

Acute lung injury (ALI) is a common lung pathology that is accompanied by alveolar
macrophage (AM) activation and inflammatory response. This study investigated the role of …

Sepsis is characterized by organ dysfunction due to a dysregulated immune response to
infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as …

Atherosclerosis is a risk factor for various cardiovascular diseases, and is linked to high
rates of morbidity and mortality across the globe. Although numerous complex processes …

Inflammasome activation is an essential innate immune defense mechanism against
Salmonella infections. Salmonella has developed multiple strategies to avoid or delay …

Background Inhibition of sphingosine kinase 1 (SphK1), which catalyzes bioactive lipid
sphingosine-1–phosphate (S1P), attenuates NLRP3 inflammasome activation. S1P exerts …

Sepsis is a life-threatening syndrome with disturbed host responses to severe infections,
accounting for the majority of death in hospitalized patients. However, effective medicines …

Myocardial injury is the primary manifestation of multiple organ dysfunction during sepsis,
however, the mechanisms underlying sepsis‑induced myocardial injury remain unclear …

Protectin conjugates in tissue regeneration 1 (PCTR1) is a novel anti-inflammatory and
proresolving lipid mediator biosynthesized from docosahexaenoic acid. Excessive activation …

Acute kidney injury (AKI) is a global public health hazard with high morbidity and mortality.
Sepsis accounts for nearly half of all causes of AKI. Scientists have made a great effort to …