Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Among various nanoparticles, superparamagnetic iron oxide nanoparticles (SPIONs) have
been increasingly studied for their excellent superparamagnetism, magnetic heating …

Tumor-induced bone loss is the main reason causing bone tumor therapy failure. Rational
design of implants with both anti-tumor and bone tissue regeneration functions is urgently …

Purpose The objective of this study was to investigate the antitumor activity, targeting
capability, and mechanism of the developed nanodrug consisting of doxorubicin and …

Background Tyrosine kinase inhibitors have shown activity in osteosarcoma and might
enhance the efficacy of chemotherapy. We aimed to determine the recommended phase 2 …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

Bone is an alive and dynamic organ that is well-differentiated and originated from
mesenchymal tissues. Bone undergoes continuous remodeling during the lifetime of an …

Successful repair of critical-sized tumor-resection defects, especially in load-bearing bones,
still remains a major challenge in clinical orthopedics. Titanium (Ti) implants have been …

Background Osteosarcoma, a primary malignant bone tumor derived from mesenchymal
tissue, is the most common type of pleomorphic tumor that occurs in children and …