Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult
population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain …

Immune checkpoint receptors are key players in regulating the immune response. They are
responsible for both generating an immune response sufficient to kill invading pathogens …

The majority of lncRNAs' roles in tumor immunology remain elusive. This project performed
a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human …

Obesity manifests itself with low-grade chronic inflammation that shapes immune responses
during infection. Albeit obese individuals are at risk of higher mortality due to comorbidities …

Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe
chronic liver disease and primary liver cancer. Chronic infection remains for life if not …

CD8+ T cells are crucial for the clearance of viral infections, and current research begins to
highlight their importance in parasitic diseases too. In-depth research about characteristics …

Background Exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs), characterized by the
overexpression of immune checkpoints (IC), is a major impediment to anti-tumor immunity …

Neglected tropical parasitic diseases (NTD) are prevalent in many countries and cost-
effective treatments remain urgently needed. Novel approaches have been proposed to …

Background T-cell responses during chronic viral infections become exhausted, which is
reflected by upregulation of inhibitory receptors (iRs) and increased interleukin 10 (IL-10) …

Background Viral hepatitis is a widespread and serious infectious disease, and most
patients with liver cirrhosis and hepatocellular carcinoma are prone to viral infections. T cell …