Glycosaminoglycans from marine sources as therapeutic agents

J Valcarcel, R Novoa-Carballal, RI Pérez-Martín… - Biotechnology …, 2017 - Elsevier
Glycosaminoglycans (GAGs) in marine animals are different to those of terrestrial organisms,
mainly in terms of molecular weight and sulfation. The therapeutic properties of GAGs are …

Engineered sulfated polysaccharides for biomedical applications

Ø Arlov, D Rütsche, M Asadi Korayem… - Advanced Functional …, 2021 - Wiley Online Library
Sulfated polysaccharides are ubiquitous in living systems and have central roles in
biological functions such as organism development, cell proliferation and differentiation …

GlycoTorch Vina: docking designed and tested for glycosaminoglycans

ED Boittier, JM Burns, NS Gandhi… - Journal of Chemical …, 2020 - ACS Publications
Glycosaminoglycans (GAGs) are a family of anionic carbohydrates that play an essential
role in the physiology and pathology of all eukaryotic life forms. Experimental determination …

Involvement of chondroitin 6-sulfation in temporal lobe epilepsy

N Yutsudo, H Kitagawa - Experimental neurology, 2015 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs) are predominant components of the extracellular
matrix in the central nervous system (CNS). Previously, we found an increase in the 4 …

Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation

VS Ushakov, AY Tsidulko… - International journal of …, 2017 - mdpi.com
Heparan sulfate (HS) is an important component of the extracellular matrix and cell surface,
which plays a key role in cell–cell and cell–matrix interactions. Functional activity of HS …

Synthetic xylosides: probing the glycosaminoglycan biosynthetic machinery for biomedical applications

JS Chua, B Kuberan - Accounts of Chemical Research, 2017 - ACS Publications
Conspectus Glycosaminoglycans (GAGs) are polysaccharides ubiquitously found on cell
surfaces and in the extracellular matrix (ECM). They regulate numerous cellular signaling …

CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics …

J Melrose - Journal of Neuroscience Research, 2024 - Wiley Online Library
Central and peripheral nervous system (CNS/PNS) proteoglycans (PGs) have diverse
functional roles, this study examined how these control cellular behavior and tissue function …

Glycosaminoglycan microarrays for studying glycosaminoglycan–protein systems

JE Chittum, A Thompson, UR Desai - Carbohydrate Polymers, 2024 - Elsevier
More than 3000 proteins are now known to bind to glycosaminoglycans (GAGs). Yet, GAG–
protein systems are rather poorly understood in terms of selectivity of recognition, molecular …

Exploiting differential surface display of chondroitin sulfate variants for directing neuronal outgrowth

VP Swarup, TW Hsiao, J Zhang… - Journal of the …, 2013 - ACS Publications
Chondroitin sulfate (CS) proteoglycans (CSPGs) are known to be primary inhibitors of
neuronal regeneration at scar sites. However, a variety of CSPGs are also involved in …

Dexamethasone inhibits heparan sulfate biosynthetic system and decreases heparan sulfate content in orthotopic glioblastoma tumors in mice

DK Sokolov, OB Shevelev, AS Khotskina… - International Journal of …, 2023 - mdpi.com
Glioblastoma (GB) is an aggressive cancer with a high probability of recurrence, despite
active chemoradiotherapy with temozolomide (TMZ) and dexamethasone (DXM). These …