The atypical antipsychotic agent, clozapine, is used to treat a variety of neurological
disorders including schizophrenia and Parkinson's disease and readily crosses the blood …

Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Whereas
T cells are likely the main drivers of disease development, the striking efficacy of B cell …

Vitamin D is a potent immune modulator, keeping the T-cell compartment in a more
tolerogenic state. Multiple sclerosis (MS), a disease in which an autoreactive T-cell response …

Background Most studies that have investigated the association between multiple sclerosis
(MS) and cancer have suggested a reduced overall cancer risk and no effect of long-term …

Background Interferon-beta (IFNβ) regulates the expression of a complex set of pro-as well
as anti-inflammatory genes. In cohorts of MS patients unstratified for therapeutic response to …

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central
nervous system (CNS) that mostly manifests as irreversible disability. The aetiopathogenesis …

We recently showed that B cells reduce CNS inflammation in mice with experimental allergic
encephalomyelitis (EAE). Here, we demonstrate that adoptively transferred CD5/CD19+ B …

Background: There is increasing evidence on cerebrospinal fluid (CSF) oligoclonal IgM
(OCIgM) predicting a more aggressive disease course in relapsing–remitting Multiple …

Current and emerging therapies for multiple sclerosis (MS) offer promise for improved
disease control and long-term clinical outcome. To date, these therapies have been …

Growing concern about neurodegenerative diseases is becoming a global issue. It is
estimated that not only will their prevalence increase but also morbidity and health burden …