Expression of CD40 and CD192 in Classical Monocytes in Multiple Sclerosis Patients Assessed with Transcranial Magnetic Stimulation

N Režić Mužinić, A Markotić, S Pavelin, D Polančec… - Biomedicines, 2023 - mdpi.com
Expression of CD40 and CD192 markers in different monocyte subpopulations has been
reported to be altered in people with MS (pwMS). Also, functional connectivity of the …

Multiple sclerosis therapies: molecular mechanisms and future

P Fontoura, H Garren - Molecular Basis of Multiple Sclerosis: The Immune …, 2010 - Springer
The current treatments for multiple sclerosis (MS) are, by many measures, not satisfactory.
The original interferon-β therapies were not necessarily based on an extensive knowledge …

Pediatric multiple sclerosis: pathobiological, clinical, and magnetic resonance imaging features

LH Verhey, M Shroff, B Banwell - Neuroimaging …, 2013 - neuroimaging.theclinics.com
Multiple sclerosis (MS) is the most common autoimmune demyelinating disease of the
central nervous system (CNS), characterized by immunemediated inflammation and …

Emerging multiple sclerosis disease-modifying therapies

PS Giacomini, PJ Darlington… - Current opinion in …, 2009 - journals.lww.com
Several of the emerging therapies focusing on immune-mediated disease mechanisms
seem to offer stronger efficacy than the currently approved immune modulators for MS …

[PDF][PDF] Cytokines in multiple sclerosis–possible targets for immune therapies

A Trenova, G Slavov - J. Neurol Exp. Neurosci, 2016 - Citeseer
The complex interactions between the central nervous system and the immune system are
mainly mediated via synthesis and secretion of cytokines. Disturbance of the fine balance …

Natural and induced immunization against CCL20 ameliorate experimental autoimmune encephalitis and may confer protection against multiple sclerosis

M Abraham, A Karni, K Mausner-Fainberg, ID Weiss… - Clinical …, 2017 - Elsevier
Th-17 type immune response that occurs in multiple sclerosis (MS) is linked to CCR6-
CCL20 interaction. We confirmed the dependency on CCR6 in EAE development …

Drugs in clinical development for multiple sclerosis: focusing on anti-CD20 antibodies

C Gasperini, S Haggiag, S Ruggieri - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system (CNS), traditionally considered to be an autoimmune disease. Despite the standard …

MIP-3β/CCL19 is associated with the intrathecal invasion of mononuclear cells in neuroinflammatory and non-neuroinflammatory CNS diseases in dogs

J Bartels, BG Darrow, SJ Schatzberg, L Bu… - BMC veterinary …, 2014 - Springer
Background Chemokines such as MIP-3β/CCL19 are important factors in the mechanism of
cell migration and pathogenesis of central nervous system (CNS) inflammatory reactions …

Therapeutic potential of IL-27 in multiple sclerosis?

DC Fitzgerald, A Rostami - Expert opinion on biological therapy, 2009 - Taylor & Francis
Background: Multiple sclerosis (MS) is a debilitating neurological disease, characterized by
inflammatory demyelination and axonal degeneration in the CNS. Currently approved …

Chronic cerebrospinal venous insufficiency in multiple sclerosis: A sonographer-blinded case-control study

D Imperiale, F Melis, C Giaccone, M Guido… - Clinical Neurology and …, 2013 - Elsevier
Objectives To evaluate the presence of chronic cerebrospinal venous insufficiency (CCSVI)
and cerebral venous anomalies in a consecutive series of patients with multiple sclerosis …