Currently, there are about 7000 identified rare diseases, together affecting 10% of the
population. However, fewer than 6% of all rare diseases have an approved treatment option …

Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the
key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer …

RAS has long been viewed as undruggable due to its lack of deep pockets for binding of
small molecule inhibitors. However, recent successes in the development of direct RAS …

CRISPR/Cas9-based therapies hold considerable promise for the treatment of genetic
diseases. Among these, Hutchinson–Gilford progeria syndrome, caused by a point mutation …

Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder
characterized by premature death from myocardial infarction or stroke. It is caused by de …

Approximately 20% of the world's population will be around or above 65 years of age by the
next decade. Out of these, 40% are suspected to have cardiovascular diseases as a cause …

The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal
non-transcriptional functions in various biological processes critical for cellular homeostasis …