Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Angelica dahurica (A. dahurica) root is a famous edible medicinal herb that has been used
in China for thousands of years. To date, more than 300 chemical constituents have been …

Skin is innervated by a multitude of sensory nerves that are important to the function of this
barrier tissue in homeostasis and injury. The role of innervation and neuromediators has …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

The transition from acute to chronic pain is an ongoing major problem for individuals, society
and healthcare systems around the world. It is clear chronic pain is a complex …

Background Perineural invasion (PNI) has a high incidence and poor prognosis in
pancreatic ductal adenocarcinoma (PDAC). Our study aimed to identify the underlying …

Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …

Chronic pain is a common symptom experienced during cancer progression. Additionally,
some patients experience bone pain caused by cancer metastasis, which further …

Toll-like receptors (TLRs) are innate immune receptors that are expressed in immune cells
as well as glia and neurons of the central and peripheral nervous systems. They are best …

Transient receptor potential vanillic acid 1 (TRPV1) is an ion channel activated by heat and
inflammatory factors involved in the development of various types of pain. The P2X7 …