The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Cardiometabolic diseases are the leading cause of death worldwide. Despite a known
genetic component, our understanding of these diseases remains incomplete. Here, we …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological
feature of which is the death of dopamine neurons in the substantia nigra region. At present …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …

The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3)
inflammasome is a component of the inflammatory process, and its aberrant activation is …

Fluorescence monitoring of ATP in different organelles is now feasible with a few biosensors
developed, which, however, show low sensitivity, limited biocompatibility, and accessibility …

It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …