PGE 2, an essential homeostatic factor, is also a key mediator of immunopathology in
chronic infections and cancer. The impact of PGE 2 reflects the balance between its …

Tremendous advances in understanding the structure and function of the superfamily of
phospholipase A 2 (PLA 2) enzymes has occurred in the twenty-first century. The …

Background Idiopathic membranous nephropathy, a common form of the nephrotic
syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis …

Abstract Bee venom (BV)(api-toxin) has been widely used in the treatment of some immune-
related diseases, as well as in recent times in treatment of tumors. Several cancer cells …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

The mannose receptor family comprises four glycoproteins each of which is a type I
transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II …

Phospholipase A2 (PLA2 catalyzes the hydrolysis of the sn-2 position of membrans
glyerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …

Phospholipase A2 (PLA2) constitutes a growing superfamily of lipolytic enzymes, and to
date, at least 19 distinct enzymes have been found in mammals. This class of enzymes has …