PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis
L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …
A family affair: var genes, PfEMP1 binding, and malaria disease
SM Kraemer, JD Smith - Current opinion in microbiology, 2006 - Elsevier
An immunovariant adhesion protein family in Plasmodium falciparum named erythrocyte
membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic …
membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic …
Plasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes
ATR Jensen, P Magistrado, S Sharp… - The Journal of …, 2004 - rupress.org
Parasite-encoded variant surface antigens (VSAs) like the var gene–encoded Plasmodium
falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic …
falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic …
[HTML][HTML] Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria
The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and
must retain the ability to bind to host receptors while also diversifying to aid immune evasion …
must retain the ability to bind to host receptors while also diversifying to aid immune evasion …
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
MD Larsen, M Lopez-Perez, EK Dickson… - Nature …, 2021 - nature.com
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …
A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells
M Avril, AK Tripathi, AJ Brazier… - Proceedings of the …, 2012 - National Acad Sciences
Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …
Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
Virulence in malaria: an evolutionary viewpoint
MJ Mackinnon, AF Read - Philosophical Transactions of …, 2004 - royalsocietypublishing.org
Malaria parasites cause much morbidity and mortality to their human hosts. From our
evolutionary perspective, this is because virulence is positively associated with parasite …
evolutionary perspective, this is because virulence is positively associated with parasite …
Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family
SM Kraemer, JD Smith - Molecular microbiology, 2003 - Wiley Online Library
The var gene family encodes Plasmodium falciparum erythrocyte membrane 1 (PfEMP1)
proteins that act as virulence factors responsible for both antigenic variation and …
proteins that act as virulence factors responsible for both antigenic variation and …
Differential Expression of var Gene Groups Is Associated with Morbidity Caused by Plasmodium falciparum Infection in Tanzanian Children
M Rottmann, T Lavstsen, JP Mugasa… - Infection and …, 2006 - Am Soc Microbiol
The var gene family of Plasmodium falciparum encodes the variant surface antigen
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 is considered …
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 is considered …