Background. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates
the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues …

In Plasmodium falciparum, var genes encode adhesive proteins that are transported to the
surface of infected erythrocytes and act as major virulence determinants for infected …

The binding of erythrocytes infected with mature blood stage parasites to the vascular bed is
key to the pathogenesis of malignant malaria. The binding is mediated by members of …

Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the
number of genetically distinct parasite strains co-infecting a single host, which is an …

Antigenic variation in Plasmodium falciparum malaria is mediated by transcriptional
switches between different members of the multicopy var gene family. Each var gene …

The Plasmodium falciparum erythrocyte membrane protein 1 antigens that are inserted onto
the surface of P. falciparum infected erythrocytes play a key role both in the pathology of …

Malaria persists as an undiminished global problem, but the resources available to address
it have increased. Many tools for understanding its biology and epidemiology are well …

Plasmodium falciparum being the most lethal plasmodiae is still a major cause of the
disease burden and mortality in malaria endemic areas. Due to the wide spread drug …

Reversing the spread of HIV infection and the incidence of malaria constitute two of the
Millenium Development Goals. However, despite recent achievements, both diseases still …

Sequence diversity in pathogen antigens is an obstacle to the development of interventions
against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 …