The COVID-19 pandemic
M Ciotti, M Ciccozzi, A Terrinoni, WC Jiang… - Critical reviews in …, 2020 - Taylor & Francis
In December 2019, an outbreak of pneumonia of unknown origin was reported in Wuhan,
Hubei Province, China. Pneumonia cases were epidemiologically linked to the Huanan …
Hubei Province, China. Pneumonia cases were epidemiologically linked to the Huanan …
[HTML][HTML] Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
[HTML][HTML] Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
MM Zhao, WL Yang, FY Yang, L Zhang… - Signal transduction and …, 2021 - nature.com
To discover new drugs to combat COVID-19, an understanding of the molecular basis of
SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of …
SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of …
Current status of plant metabolite-based fabrication of copper/copper oxide nanoparticles and their applications: a review
KS Siddiqi, A Husen - Biomaterials Research, 2020 - spj.science.org
Since green mode of nanoparticles (NPs) synthesis is simple, advantageous and
environment friendly relative to chemical and physical procedures, various plant species …
environment friendly relative to chemical and physical procedures, various plant species …
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
[HTML][HTML] Multi-organ proteomic landscape of COVID-19 autopsies
X Nie, L Qian, R Sun, B Huang, X Dong, Q Xiao… - Cell, 2021 - cell.com
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
[HTML][HTML] COVID-19 and cancer: current challenges and perspectives
Patients with cancer have been disproportionately affected by the COVID-19 pandemic. This
effect has included the adverse outcomes in patients with cancer who develop COVID-19 …
effect has included the adverse outcomes in patients with cancer who develop COVID-19 …
An updated review of computer‐aided drug design and its application to COVID‐19
The recent outbreak of the deadly coronavirus disease 19 (COVID‐19) pandemic poses
serious health concerns around the world. The lack of approved drugs or vaccines continues …
serious health concerns around the world. The lack of approved drugs or vaccines continues …
SARS-CoV-2 main protease drug design, assay development, and drug resistance studies
Conspectus SARS-CoV-2 is the etiological pathogen of the COVID-19 pandemic, which led
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …
to more than 6.5 million deaths since the beginning of the outbreak in December 2019. The …