[HTML][HTML] Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps

MS Stroe, L Van Bockstal, A Valenzuela… - Frontiers in …, 2023 - frontiersin.org
Animal models provide useful information on mechanisms in human disease conditions, but
also on exploring (patho) physiological factors affecting pharmacokinetics, safety, and …

Rate-and Region-Dependent Mechanical Properties of Göttingen Minipig Brain Tissue in Simple Shear and Unconfined Compression

GM Boiczyk, N Pearson, VB Kote… - Journal of …, 2023 - asmedigitalcollection.asme.org
Traumatic brain injury (TBI), particularly from explosive blasts, is a major cause of casualties
in modern military conflicts. Computational models are an important tool in understanding …

Strain-induced collagen denaturation is rate dependent in failure of cerebral arteries

WJ Anderl, N Pearson, MI Converse, SM Yu… - Acta Biomaterialia, 2023 - Elsevier
While soft tissues are commonly damaged by mechanical loading, the manifestation of this
damage at the microstructural level is not fully understood. Specifically, while rate-induced …

Dynamic cerebral autoregulation is governed by two time constants: Arterial transit time and feedback time constant

SJ Payne - The Journal of Physiology, 2024 - Wiley Online Library
Dynamic cerebral autoregulation (dCA) is the mechanism that describes how the brain
maintains cerebral blood flow approximately constant in response to short‐term changes in …