Genetic and epigenetic determinants of diffuse large B-cell lymphoma
TJ Bakhshi, PT Georgel - Blood cancer journal, 2020 - nature.com
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma and is
notorious for its heterogeneity, aggressive nature, and the frequent development of …
notorious for its heterogeneity, aggressive nature, and the frequent development of …
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
Natural infections expose the immune system to escalating antigen and inflammation over
days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the …
days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the …
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
Failure of immunization with the HIV-1 envelope to induce broadly neutralizing antibodies
against conserved epitopes is a major barrier to producing a preventive HIV-1 vaccine …
against conserved epitopes is a major barrier to producing a preventive HIV-1 vaccine …
Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination
L Verkoczy, M Diaz - Current Opinion in HIV and AIDS, 2014 - journals.lww.com
It is increasingly apparent that immune tolerance, sometimes invoked by self-reactivity that
overlaps with bnAb epitope specificity, adds to a formidable set of roadblocks impeding …
overlaps with bnAb epitope specificity, adds to a formidable set of roadblocks impeding …
[HTML][HTML] Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies
Generation of potent antibodies by a mutation-selection process called affinity maturation is
a key component of effective immune responses. Antibodies that protect against highly …
a key component of effective immune responses. Antibodies that protect against highly …
[HTML][HTML] Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain
The Omicron variant of SARS-CoV-2 is not effectively neutralized by most antibodies elicited
by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing …
by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing …
Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
V Ovchinnikov, JE Louveau, JP Barton, M Karplus… - Elife, 2018 - elifesciences.org
Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly
mutable pathogens (eg, HIV, influenza) could be key for developing effective universal …
mutable pathogens (eg, HIV, influenza) could be key for developing effective universal …
Two complementary features of humoral immune memory confer protection against the same or variant antigens
M Van Beek, MC Nussenzweig… - Proceedings of the …, 2022 - National Acad Sciences
The humoral immune response, a key arm of adaptive immunity, consists of B cells and their
products. Upon infection or vaccination, B cells undergo a Darwinian evolutionary process in …
products. Upon infection or vaccination, B cells undergo a Darwinian evolutionary process in …
Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development.
bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of …
bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of …
Defining and manipulating B cell immunodominance hierarchies to elicit broadly neutralizing antibody responses against influenza virus
The antibody repertoire possesses near-limitless diversity, enabling the adaptive immune
system to accommodate essentially any antigen. However, this diversity explores the …
system to accommodate essentially any antigen. However, this diversity explores the …