TOPIIA topoisomerases are required for the regulation of DNA topology by DNA cleavage
and re-ligation and are important targets of antibiotic and anticancer agents. Humans …

Objective A combination of antibiotics, including but not limited to metronidazole (MET) and
ciprofloxacin (CIP), has been indicated to eradicate bacteria in necrotic immature permanent …

African swine fever virus (ASFV) is the causal agent of African swine fever (ASF), which is
contagious and highly lethal to domestic pigs and wild boars. The genome of ASFV encodes …

The transition from the RNA to the DNA world was a major event in the history of life. The
invention of DNA required the appearance of enzymatic activities for both synthesis of DNA …

Meiotic recombination is initiated by DNA double-stranded break (DSB) formation catalyzed
by Spo11, a type-II topoisomerase-like transesterificase, presumably via a dimerization …

Abstract The AraC/XylS family of transcription factors, which include proteins that are
involved in the regulation of diverse biological processes, has been of considerable interest …

Abstract DNA Topoisomerase I (TopoI) in eubacteria is the principle DNA relaxase,
belonging to Type 1A group. The enzyme from Mycobacterium smegmatis is essential for …

Meiosis is an essential step in gametogenesis which is the key process in sexually
reproducing organisms as meiotic aberrations may result in infertility. In meiosis …

The continuing rise in cancer morbidity and mortality all over the world makes cancer the No.
2 cause of death in humans, posing a major public health challenge. Currently, surgery …

As only the type II topoisomerase is capable of introducing negative supercoiling, DNA
gyrase is involved in crucial cellular processes. Although the other domains of DNA gyrase …