Molecular mechanisms and regulation of recombination frequency and distribution in plants
Key message Recent developments in understanding the distribution and distinctive
features of recombination hotspots are reviewed and approaches are proposed to increase …
features of recombination hotspots are reviewed and approaches are proposed to increase …
SUMO modification of DNA topoisomerase II: trying to get a CENse of it all
MT Lee, J Bachant - DNA repair, 2009 - Elsevier
DNA topoisomerase II (topo II) is an essential determinant of chromosome structure and
function, acting to resolve topological problems inherent in recombining, transcribing …
function, acting to resolve topological problems inherent in recombining, transcribing …
Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol
KD Corbett, JM Berger - Nucleic acids research, 2006 - academic.oup.com
Members of the GHL ATPase superfamily, including type II topoisomerases, Hsp90-class
chaperones, and MutL, all share a common GHKL-type ATP-binding fold and act as …
chaperones, and MutL, all share a common GHKL-type ATP-binding fold and act as …
Topoisomerases of kinetoplastid parasites: why so fascinating?
BB Das, T Sengupta, A Ganguly… - Molecular …, 2006 - Wiley Online Library
DNA topoisomerases are the key enzymes involved in carrying out high precision DNA
transactions inside the cells. However, they are detrimental to the cell when a wide variety of …
transactions inside the cells. However, they are detrimental to the cell when a wide variety of …
Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol
D Gadelle, C Bocs, M Graille… - Nucleic acids research, 2005 - academic.oup.com
Type II DNA topoisomerases have been classified into two families, Topo IIA and Topo IIB,
based on structural and mechanistic dissimilarities. Topo IIA is the target of many important …
based on structural and mechanistic dissimilarities. Topo IIA is the target of many important …
[HTML][HTML] Review and Current Perspectives on DNA Topoisomerase I and II Enzymes of Fungi as Study Models for the Development of New Antifungal Drugs
Fungal infections represent a growing public health problem, mainly stemming from two
phenomena. Firstly, certain diseases (eg, AIDS and COVID-19) have emerged that weaken …
phenomena. Firstly, certain diseases (eg, AIDS and COVID-19) have emerged that weaken …
DNA topoisomerases of Leishmania parasites; druggable targets for drug discovery
RM Reguera, EK Elmahallawy… - Current Medicinal …, 2019 - ingentaconnect.com
DNA topoisomerases (Top) are a group of isomerase enzymes responsible for controlling
the topological problems caused by DNA double helix in the cell during the processes of …
the topological problems caused by DNA double helix in the cell during the processes of …
Meiotic recombination protein Rec12: functional conservation, crossover homeostasis and early crossover/non-crossover decision
F Kan, MK Davidson, WP Wahls - Nucleic acids research, 2011 - academic.oup.com
In fission yeast and other eukaryotes, Rec12 (Spo11) is thought to catalyze the formation of
dsDNA breaks (DSBs) that initiate homologous recombination in meiosis. Rec12 is …
dsDNA breaks (DSBs) that initiate homologous recombination in meiosis. Rec12 is …
Breakage-Reunion Domain of Streptococcus pneumoniae Topoisomerase IV: Crystal Structure of a Gram-Positive Quinolone Target
I Laponogov, DA Veselkov, MK Sohi, XS Pan… - PLoS …, 2007 - journals.plos.org
The 2.7 Å crystal structure of the 55-kDa N-terminal breakage-reunion domain of
topoisomerase (topo) IV subunit A (ParC) from Streptococcus pneumoniae, the first for the …
topoisomerase (topo) IV subunit A (ParC) from Streptococcus pneumoniae, the first for the …