To achieve longevity, IgA plasma cells require a sophisticated anatomical microenvironment
that provides cytokines, cell-cell contacts, and nutrients as well as metabolites. The intestinal …

Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …

Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-
related environmental pollutants may contribute to the pathogenesis of various diseases and …

Abstract In October 2022, the World Health Organization (WHO) convened an expert panel
in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds …

The aryl hydrocarbon receptor (AhR) is a transcription factor deeply implicated in health and
diseases. Historically identified as a sensor of xenobiotics and mainly toxic substances, AhR …

The aryl hydrocarbon receptor (AHR) is a ubiquitously expressed ligand-activated
transcription factor with multifaceted physiological functions. In the immune system, AHR has …

The accumulation of the uremic toxin indoxyl sulfate (IS) induces target organ damage in
chronic kidney disease (CKD) patients, and causes complications including cardiovascular …

Dioxin and dioxin-like compounds are chlorinated organic pollutants formed during the
manufacturing of other chemicals. Dioxins are ligands of the aryl hydrocarbon receptor …

Breast cancer is the most common invasive malignancy among women worldwide and
constitutes a complex and heterogeneous disease. Interest has recently grown in the role of …

The aryl hydrocarbon receptor (AhR) is a key regulator in the microbiome-gut-brain axis, and
AhR-active microbial metabolites modulate multiple neuronal responses. We recently …