Molecular mechanisms, biomarkers and emerging therapies for chemotherapy resistant TNBC

P Ferrari, C Scatena, M Ghilli, I Bargagna… - International journal of …, 2022 - mdpi.com
Triple-negative breast cancer (TNBC) is associated with high recurrence rates, high
incidence of distant metastases, and poor overall survival (OS). Taxane and anthracycline …

Molecular classification, treatment, and genetic biomarkers in triple-negative breast cancer: a review

B Lu, E Natarajan… - … in Cancer Research …, 2023 - journals.sagepub.com
Breast cancer is the most common malignancy and the second most common cause of
cancer-related mortality in women. Triple-negative breast cancers do not express estrogen …

MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression

J Lin, A Xu, J Jin, M Zhang, J Lou, C Qian, J Zhu… - …, 2022 - Taylor & Francis
The poor progress of immunotherapy on osteosarcoma patients requires deeper delineation
of immune tolerance mechanisms in the osteosarcoma microenvironment and a new …

Validation of Dual-Action Chemo-Radio-Labeled Nanocarriers with High Efficacy against Triple-Negative Breast Cancer

S Ilyas, S EM Sahnoun, A Szymura, J Pes… - … applied materials & …, 2023 - ACS Publications
Identification and selectivity of molecular targets with prolonged action for difficult-to-target
cancer such as triple-negative breast cancer (TNBC) represent a persisting challenge in the …

Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

N Garmpis, C Damaskos, D Dimitroulis… - Journal of Personalized …, 2022 - mdpi.com
Background/Aim: There is a strong association between malignancy and histone
deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) are now being tested as …

Compounds from diverse natural origin against triple‐negative breast cancer: A comprehensive review

R Thilagavathi, S Priyankha, M Kannan… - Chemical Biology & …, 2023 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is caused due to the lack of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor 2 (HER2) expression …

Identification of indole-based natural compounds as inhibitors of PARP-1 against triple-negative breast cancer: a computational study

S Priyankha, V Rajapandian… - Journal of …, 2024 - Taylor & Francis
Triple-negative breast cancer (TNBC) is the most aggressive kind of breast cancer known to
mankind. It is a heterogeneous disease that is formed due to the missing estrogen …

Additive pharmacological interaction between sirtuin inhibitor cambinol and paclitaxel in MCF7 luminal and MDA-MB-231 triple-negative breast cancer cells

A Wawruszak, E Okon, I Telejko, A Czerwonka… - Pharmacological …, 2022 - Springer
Background Breast cancer (BC) is the most common malignancy and the leading cause of
cancer-related death in women worldwide. Sirtuin inhibitors (SIRTi), belonging to the histone …

[HTML][HTML] A novel immune-related long noncoding RNA (lncRNA) pair model to predict the prognosis of triple-negative breast cancer

JY Li, CJ Hu, H Peng, EQ Chen - Translational Cancer Research, 2024 - ncbi.nlm.nih.gov
Background Breast cancer (BC) is the most prevalent cancer type and is the principal cause
of cancer-related death in women. Anti-programmed cell death protein 1/programmed cell …

A Novel Immune-Related LncRNA Pair Model to Predict the Prognosis of Triple-Negative Breast Cancer

J Li, P Fan, H Peng, S Wang, EQ Chen - 2023 - researchsquare.com
Background Breast cancer (BC) is the most prevalent cancer type and is the principal cause
of cancer-related death in women. Anti-PD-1/PD-L1 immunotherapy has shown promising …