In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …

Histopathological classifications of neuroendocrine neoplasms (NEN) change regularly and
the latest WHO classification published in 2022, which concerns all NEN in the body …

Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …

Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …

Background Pancreatic neuroendocrine tumors (pNETs) are rare cancers with outcomes
determined by multiple factors including grade, stage, and clinical presentation. In this study …

Gastrinomas are neuroendocrine neoplasms (NENs), that occur primarily in the duodenum
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …

Common to neuroendocrine neoplasms of the pancreas is their expression of
synaptophysin, chromogranin A, and/or INSM1. They differ, however, in their histological …

Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine
tumors (PanNETs) with associated clinical and genomic information. We identified three …

Gastroenteropancreatic neuroendocrine neoplasia (GEPNEN) comprises clinically as well
as prognostically diverse tumour entities often diagnosed at late stage. Current classification …

Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively
benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the …