Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Importance The totality of the societal and individual impact of treatment-resistant
depression (TRD) is unknown, as is the potential to prognosticate TRD. The generalizability …

Concurrent with recent insights into the neuroprogressive nature of depression, ketamine
shows promise in interfering with several neuroprogressive factors, and has been suggested …

While antidepressants may be effective in treating depression for some people, a third of
people do not have an improvement in mood after a trial of two different antidepressants for …

Background Subanesthetic ketamine has accumulated meta-analytic evidence for rapid
antidepressant effects in treatment-resistant depression (TRD), resulting in both excitement …

Emotional distress has been rising since before the COVID-19 pandemic and the public is
told that depression is a major public health problem. For example, in 2017 depressive …

Objective: Radically open dialectical behavior therapy (RO DBT) is an empirically supported
psychotherapy for treatment-refractory depression (TRD) that targets psychological …

We present the first evidence that sub-anesthetic ketamine infusions for treatment resistant
depression (TRD) may facilitate deprescription of long-term benzodiazepine/z-drugs …

Background Trauma has been increasingly linked to depression. Previous studies have
suggested that comorbid post-traumatic stress disorder (PTSD) may be associated with poor …

Background Patients with chronic depression (CD) typically have an early symptom onset,
more psychiatric comorbidities, more treatment attempts, and more frequent and longer …