Human cytomegalovirus (HCMV), a betaherpesvirus, can cause life-threatening disease in
immunocompromised individuals. Viral envelope glycoproteins that mediate binding to and …

In retinal pigment epithelial (RPE) cells, transforming growth factor-beta (TGF-β) plays a
critical role in epithelial-mesenchymal transition (EMT), which contributes to various fibrotic …

Simple Summary Breast cancer-related deaths are mainly due to the spread of cancer cells
to distant organs (a process termed metastasis). CD82, also known as KAI1, is an …

Tetraspanins are multiple membrane-spanning proteins that likely function as the organizers
of membrane microdomains. Tetraspanins associate with other membrane-bound molecules …

During the assembly of human immunodeficiency virus type 1 (HIV-1) particles, the
tetraspanin CD63 can be incorporated into the viral membrane. Indeed, cell surface …

Human cytomegalovirus (HCMV) depends on and modulates multiple host cell membrane
proteins during each stage of the viral life cycle. To gain a global view of the impact of HCMV …

Tetraspanins belong to the transmembrane 4 superfamily (TM4SF), which span the cell
membrane 4 times and act as bridges or connectors. Increasing evidences have shown that …

CD4 is engaged in APC-mediated T-cell activation and serves as the primary receptor for
HIV. CD4 dimerization and location in specific microdomains has been previously …

Directed release of human immunodeficiency virus type 1 (HIV-1) into the cleft of the
virological synapse that can form between infected and uninfected T cells, for example, in …

Burkholderia pseudomallei is the causative agent of melioidosis, a disease with high
morbidity that is endemic in South East Asia and northern Australia. An unusual feature of …