The vitamin D receptor as a potential target for the treatment of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's diseases: A narrative …

W Lasoń, D Jantas, M Leśkiewicz, M Regulska… - Cells, 2023 - mdpi.com
The vitamin D receptor (VDR) belongs to the nuclear receptor superfamily of transcription
factors. The VDR is expressed in diverse brain regions and has been implicated in the …

Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism

P Lindholm, M Saarma - Molecular psychiatry, 2022 - nature.com
Midbrain dopamine neurons deteriorate in Parkinson's disease (PD) that is a progressive
neurodegenerative movement disorder. No cure is available that would stop the …

[HTML][HTML] Real-time selective detection of dopamine and serotonin at nanomolar concentration from complex in vitro systems

S Rantataro, I Parkkinen, M Airavaara… - Biosensors and …, 2023 - Elsevier
Electrochemical sensors provide means for real-time monitoring of neurotransmitter release
events, which is a relatively easy process in simple electrolytes. However, this does not …

Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies

P Chmielarz, M Saarma - Pharmacological Reports, 2020 - Springer
Background Neurotrophic factors are endogenous proteins promoting the survival of
different neural cells. Therefore, they elicited great interest as a possible treatment for …

The molecular pathway of p75 neurotrophin receptor (p75NTR) in Parkinson's disease: The way of new inroads

NH Ali, HM Al-Kuraishy, AI Al-Gareeb, SA Alnaaim… - Molecular …, 2024 - Springer
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease of the
brain. PD is characterized by motor and non-motor symptoms. The p75 neurotrophin …

CDNF and ER stress: Pharmacology and therapeutic possibilities

H Lõhelaid, M Saarma, M Airavaara - Pharmacology & Therapeutics, 2024 - Elsevier
Cerebral dopamine neurotrophic factor (CDNF) is an endogenous protein in humans and
other vertebrates, and it has been shown to have protective and restorative effects on cells in …

The links between Parkinson's disease and cancer

M Ejma, N Madetko, A Brzecka, K Guranski, P Alster… - Biomedicines, 2020 - mdpi.com
Epidemiologic studies indicate a decreased incidence of most cancer types in Parkinson's
disease (PD) patients. However, some neoplasms are associated with a higher risk of …

Application of in vitro metabolism activation in high-throughput screening

M Ooka, C Lynch, M Xia - International journal of molecular sciences, 2020 - mdpi.com
In vitro methods which incorporate metabolic capability into the assays allow us to assess
the activity of metabolites from their parent compounds. These methods can be applied into …

Parkinson's disease: exploring different animal model systems

E Khan, I Hasan, ME Haque - International journal of molecular sciences, 2023 - mdpi.com
Disease modeling in non-human subjects is an essential part of any clinical research. To
gain proper understanding of the etiology and pathophysiology of any disease, experimental …

Can growth factors cure Parkinson's disease?

YA Sidorova, M Saarma - Trends in Pharmacological Sciences, 2020 - cell.com
Growth factors (GFs) hold considerable promise for disease modification in
neurodegenerative disorders because they can protect and restore degenerating neurons …