The vitamin D receptor as a potential target for the treatment of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's diseases: A narrative …
W Lasoń, D Jantas, M Leśkiewicz, M Regulska… - Cells, 2023 - mdpi.com
The vitamin D receptor (VDR) belongs to the nuclear receptor superfamily of transcription
factors. The VDR is expressed in diverse brain regions and has been implicated in the …
factors. The VDR is expressed in diverse brain regions and has been implicated in the …
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism
P Lindholm, M Saarma - Molecular psychiatry, 2022 - nature.com
Midbrain dopamine neurons deteriorate in Parkinson's disease (PD) that is a progressive
neurodegenerative movement disorder. No cure is available that would stop the …
neurodegenerative movement disorder. No cure is available that would stop the …
[HTML][HTML] Real-time selective detection of dopamine and serotonin at nanomolar concentration from complex in vitro systems
Electrochemical sensors provide means for real-time monitoring of neurotransmitter release
events, which is a relatively easy process in simple electrolytes. However, this does not …
events, which is a relatively easy process in simple electrolytes. However, this does not …
Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies
P Chmielarz, M Saarma - Pharmacological Reports, 2020 - Springer
Background Neurotrophic factors are endogenous proteins promoting the survival of
different neural cells. Therefore, they elicited great interest as a possible treatment for …
different neural cells. Therefore, they elicited great interest as a possible treatment for …
The molecular pathway of p75 neurotrophin receptor (p75NTR) in Parkinson's disease: The way of new inroads
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease of the
brain. PD is characterized by motor and non-motor symptoms. The p75 neurotrophin …
brain. PD is characterized by motor and non-motor symptoms. The p75 neurotrophin …
CDNF and ER stress: Pharmacology and therapeutic possibilities
Cerebral dopamine neurotrophic factor (CDNF) is an endogenous protein in humans and
other vertebrates, and it has been shown to have protective and restorative effects on cells in …
other vertebrates, and it has been shown to have protective and restorative effects on cells in …
The links between Parkinson's disease and cancer
Epidemiologic studies indicate a decreased incidence of most cancer types in Parkinson's
disease (PD) patients. However, some neoplasms are associated with a higher risk of …
disease (PD) patients. However, some neoplasms are associated with a higher risk of …
Application of in vitro metabolism activation in high-throughput screening
In vitro methods which incorporate metabolic capability into the assays allow us to assess
the activity of metabolites from their parent compounds. These methods can be applied into …
the activity of metabolites from their parent compounds. These methods can be applied into …
Parkinson's disease: exploring different animal model systems
Disease modeling in non-human subjects is an essential part of any clinical research. To
gain proper understanding of the etiology and pathophysiology of any disease, experimental …
gain proper understanding of the etiology and pathophysiology of any disease, experimental …
Can growth factors cure Parkinson's disease?
YA Sidorova, M Saarma - Trends in Pharmacological Sciences, 2020 - cell.com
Growth factors (GFs) hold considerable promise for disease modification in
neurodegenerative disorders because they can protect and restore degenerating neurons …
neurodegenerative disorders because they can protect and restore degenerating neurons …