INTRODUCTION Dendritic cells (DC) are professional antigen-presenting cells that
orchestrate immune responses. The human DC population comprises multiple subsets …

Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Drug repositioning and repurposing can enhance traditional drug development efforts and
could accelerate the identification of new treatments for individuals with Alzheimer disease …

Background System-wide profiling of genes and proteins in mammalian cells produce lists of
differentially expressed genes/proteins that need to be further analyzed for their collective …

Precision medicine is about matching the right drugs to the right patients. Although this
approach is technology agnostic, in cancer there is a tendency to make precision medicine …

There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …

Despite all modern advances in medicine, an effective drug treatment of obesity has not
been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity …

Drug target identification is a crucial step in development, yet is also among the most
complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that …

ConsensusPathDB consists of a comprehensive collection of human (as well as mouse and
yeast) molecular interaction data integrated from 32 different public repositories and a web …