[HTML][HTML] Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

Y Ma, AJ Mouton, ML Lindsey - Translational Research, 2018 - Elsevier
Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

MMP-9 signaling in the left ventricle following myocardial infarction

RP Iyer, M Jung, ML Lindsey - American Journal of …, 2016 - journals.physiology.org
Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of cardiac
wound healing responses that involve both the stimulation of robust inflammation to clear …

Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure

HB Sager, M Hulsmans, KJ Lavine, MB Moreira… - Circulation …, 2016 - Am Heart Assoc
Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …

Temporal neutrophil polarization following myocardial infarction

Y Ma, A Yabluchanskiy, RP Iyer… - Cardiovascular …, 2016 - academic.oup.com
Aims Although macrophage phenotypes have been well studied in the myocardial infarction
(MI) setting, this study investigated temporal neutrophil polarization and activation …

Infarct in the heart: what's MMP-9 got to do with it?

M Becirovic-Agic, U Chalise, MJ Daseke, S Konfrst… - Biomolecules, 2021 - mdpi.com
Over the past three decades, numerous studies have shown a strong connection between
matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left …

Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling

ML Lindsey - Nature Reviews Cardiology, 2018 - nature.com
Matrix metalloproteinases (MMPs) and their endogenous inhibitors have been studied in the
myocardium for the past 2 decades. An incomplete knowledge base and experimental …

Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling

ML Lindsey, RP Iyer, M Jung… - Journal of molecular and …, 2016 - Elsevier
Despite current optimal therapeutic regimens, approximately one in four patients diagnosed
with myocardial infarction (MI) will go on to develop congestive heart failure, and heart …

Is target-based drug discovery efficient? Discovery and “off-target” mechanisms of all drugs

A Sadri - Journal of Medicinal Chemistry, 2023 - ACS Publications
Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Macrophage activities in myocardial infarction and heart failure

SE Duncan, S Gao, M Sarhene… - Cardiology …, 2020 - Wiley Online Library
Heart diseases remain the major cause of death worldwide. Advances in pharmacological
and biomedical management have resulted in an increasing proportion of patients surviving …

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

RP Iyer, LE de Castro Brás, NL Patterson… - Journal of molecular and …, 2016 - Elsevier
Abstract Matrix metalloproteinase-9 (MMP-9) is robustly elevated in the first week post-
myocardial infarction (MI). Targeted deletion of the MMP-9 gene attenuates cardiac …