Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of cardiac
wound healing responses that involve both the stimulation of robust inflammation to clear …

Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …

Aims Although macrophage phenotypes have been well studied in the myocardial infarction
(MI) setting, this study investigated temporal neutrophil polarization and activation …

Over the past three decades, numerous studies have shown a strong connection between
matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left …

Matrix metalloproteinases (MMPs) and their endogenous inhibitors have been studied in the
myocardium for the past 2 decades. An incomplete knowledge base and experimental …

Despite current optimal therapeutic regimens, approximately one in four patients diagnosed
with myocardial infarction (MI) will go on to develop congestive heart failure, and heart …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Heart diseases remain the major cause of death worldwide. Advances in pharmacological
and biomedical management have resulted in an increasing proportion of patients surviving …

Abstract Matrix metalloproteinase-9 (MMP-9) is robustly elevated in the first week post-
myocardial infarction (MI). Targeted deletion of the MMP-9 gene attenuates cardiac …