Transposable elements (TEs) are recognized as major players in genome plasticity and
evolution. The high abundance of TEs in the human genome, especially the Alu and Long …

Long interspersed nuclear element 1 (LINE-1) is the only autonomous retrotransposon in
humans and new integrations are a major source of genetic variation between individuals …

Abstract Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor,
detects DNA fragments to trigger an innate immune response. Recently, accumulating …

Retrotransposons are genetic elements with the ability to replicate in the genome using
reverse transcriptase: they have been associated with the development of different …

Therapeutic applications of synthetic mRNA were proposed more than 30 years ago, and
are currently the basis of one of the vaccine platforms used at a massive scale as part of the …

Retrotransposons have generated about half of the human genome and LINE-1s (L1s) are
the only autonomously active retrotransposons. The cell has evolved an arsenal of defense …

The long interspersed element 1 (LINE-1 or L1) integration is affected by many cellular
factors through various mechanisms. Some of these factors are required for L1 amplification …

The TERT gene encodes the reverse transcriptase subunit of telomerase and is normally
transcriptionally suppressed in differentiated human cells but reactivated in cancers where …

Inflammatory breast cancer (IBC) is the most aggressive and lethal breast cancer subtype,
but lags in biomarker identification. Here, we used an improved Thermostable Group II Intron …

Over recent years, the investigation of transposable elements (TEs) has granted researchers
a deeper comprehension of their characteristics and functions, particularly regarding their …