Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

Protein–protein interactions have a key role in most biological processes, and offer attractive
opportunities for therapeutic intervention. Developing small molecules that modulate protein …

Here we have identified a surface protein, TIGIT, containing an immunoglobulin variable
domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif …

The proinflammatory cytokine interleukin 17 (IL‐17) is the founding member of a family of
secreted proteins that elicit potent cellular responses. We report a novel human IL‐17 …

Neurotrophin signaling is essential for normal nervous system development and adult
function. Neurotrophins are secreted proteins that signal via interacting with two …

This review seeks to give an overview of the current approaches to drug delivery from
scaffolds for neural tissue engineering applications. The challenges presented by attempting …

Nerve growth factor (NGF) was identified originally as a survival factor for sensory and
sympathetic neurons in the developing nervous system. In adults, NGF is not required for …

Sensitization of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by
proalgesic agents such as nerve growth factor (NGF). The currently accepted model is that …

Elevated intraocular pressure (IOP) in glaucoma causes loss of retinal ganglion cells
(RGCs) and damage to the optic nerve. Although IOP is controlled pharmacologically, no …

Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and
p75, which have been proposed to create a" high-affinity" NGF binding site through …